Nunzio Bottini, M.D.
The Burnham Institute, Cancer Research Center
With Paolo Curatolo, MD
" Regulation of tuberin tumor suppressor by tyrosine
phosphorylation: role of intracellular protein tyrosine phosphatases"
Nunzio
Bottini received his degree in Medicine in 1996 from the University of Rome
"Tor Vergata"; in 2000 he completed his residency in Clinical Immunology
at the same University. During his residency he carried out a research project
on the genetics of the low molecular weight protein tyrosine phosphatase in
human immuno-mediated diseases. Since 2000 he works as post-doctoral Fellow
in the Mustelin Laboratory at The Burnham Institute, La Jolla; his focus is
on reversible tyrosine phosphorylation of intracellular proteins and on intracellular
protein tyrosine phosphatases. Dr. Bottini's project will aim to study tyrosine
phosphorylation of tuberin - an important tumor suppressor involved in the pathogenesis
of Tuberous Sclerosis - and to isolate the tyrosine phosphatase(s) responsible
for the dephosphorylation of tuberin.
